A The Idiotypic Network An Antigen Ag Is Recognized By

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A The Idiotypic Network An Antigen Ag Is Recognized By nity. The idiotypic network in the regulation of autoimmunity: Theoretical and experimental studies. Menshikov I(1), Beduleva L(2), Frolov M(2), Abisheva N(2), Khramova T(2), Stolyarova E(2), Fomina K(2). Author information: (1)Department of Immunology and Cell Biology, Udmurt State University, 1, Universitetskaya Street, Izhevsk 426011, Russian Federation. Electronic address: [email protected]

AN AUTO-ANTIBODY, IDIOTYPIC NETWORK IS PRESENT IN HUMAN. Introduction: The idiotypic network in serum is critical to regulation of immune responses.It is not known whether a similar system is present in the common mucosal immune system. We therefore

A The Idiotypic Network An Antigen Ag Is Recognized By

The Idiotypic Network Theory. Jerne NK (1984) Idiotypic networks and other preconceived ideas. Immunol Rev 79: 5–24 PubMed CrossRef Google Scholar. Jerne NK, Roland J, Cazenave PA (1982) Recurrent idiotopes and internal images. EMBO J 1: 243–247 PubMed Google Scholar. Jerne NK (1977) The common sense of immunology. Cold Spring Harb Symp Quant Biol 41: 1 PubMed Google Scholar. Jerne NK (1974) Clonal selection in a

Self-Tolerance In A Minimal Model Of The Idiotypic Network. Already Jerne thought the idiotypic network to play an essential role in the control of autoreactive idiotypes . Today, the concept of idiotypic networks is still popular in the research on autoimmune diseases, both in theoretical studies and clinical context. Indeed, autoreactive antibodies are regularly found in healthy individuals though in low concentrations. Antibodies which escape other regulatory mechanisms can be controlled by the idiotypic network

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- Major Reference Works. Complementary structures can be found not only on antigen but also on antibodies of different idiotype or on T‐cell receptors. Thus a network of idiotypically interacting immune cells is formed, the idiotype network. The network influences the shaping of the B‐ and T‐cell repertoirs and may be relevant in the control of autoreactive clones. The therapeutic use of monoclonal antibodies against autoimmune diseases, cancer (in particular lymphoma) and a few other diseases relies on

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